Directions: Apply Clean Teeth Gel directly to the teeth with plaque and tartar buildup. Apply once daily. You'll soon notice your cat licking their lips repeatedly. This is normal and helps the gel mix with saliva and coat all surfaces of your cat's teeth and gums. For maximum effect, withhold food and water for 30 minutes before and after treatment. Tooth brushing is not necessary but will speed up the removal of softened plaque and tartar. Ordinarily, after 30 days, application can be reduced to 2 times weekly for regular maintenance.